AP Success - AP European History: Cloning Dolly the Sheep Breakthrough

"Dolly was part of a series of experiments at The Roslin Institute that were trying to develop a better method for producing genetically modified livestock. If successful, this would mean fewer animals would need to be used in future experiments. Scientists at Roslin also wanted to learn more about how cells change during development and whether a specialised cell, such as a skin or brain cell, could be used to make a whole new animal.

These experiments were carried out at The Roslin Institute by a team led by Professor Sir Ian Wilmut. Because of the nature of the research, the team was made up of many different people, including scientists, embryologists, surgeons, vets and farm staff.

Dolly was cloned from a cell taken from the mammary gland of a six-year-old Finn Dorset sheep and an egg cell taken from a Scottish Blackface sheep. She was born to her Scottish Blackface surrogate mother on 5th July 1996. Dolly’s white face was one of the first signs that she was a clone because if she was genetically related to her surrogate mother, she would have had a black face."
The University fo Edinburgh, "Making Dolly."

Question 1

Multiple choice
What was the primary goal of the experiments that led to the creation of Dolly the sheep at The Roslin Institute?
  • To develop a better method for producing genetically modified livestock.

  • To study the effects of cloning on animal behavior.

  • To create a new breed of sheep with enhanced wool quality.

  • To increase the milk production capabilities of livestock.

Question 2

Multiple choice
Which of the following best describes the team that worked on cloning Dolly the sheep?
  • A multidisciplinary team including scientists, embryologists, surgeons, vets, and farm staff.

  • A corporate-funded team focused on agricultural biotechnology.

  • An international consortium of researchers from various universities.

  • A small group of geneticists working in isolation.

Question 3

Multiple choice
What was a significant indicator that Dolly was indeed a clone of the Finn Dorset sheep?
  • The presence of unique genetic markers not found in either breed of sheep.

  • Dolly's rapid growth rate compared to other sheep.

  • Dolly's ability to produce milk at a younger age than normal.

  • Dolly's white face, which differed from her Scottish Blackface surrogate mother's black face.

Question 4

Multiple choice
Which cells were used to clone Dolly the sheep?
  • A brain cell from a Finn Dorset sheep and a liver cell from a Scottish Blackface sheep.

  • A cell from the mammary gland of a Finn Dorset sheep and an egg cell from a Scottish Blackface sheep.

  • A skin cell from a Scottish Blackface sheep and a sperm cell from a Finn Dorset sheep.

  • Two egg cells, one from a Finn Dorset sheep and one from a Scottish Blackface sheep.

Question 5

Multiple choice
What was one of the scientific interests that motivated the team at The Roslin Institute to clone Dolly?
  • To test the viability of inter-species organ transplants.

  • To learn more about how cells change during development and if a specialized cell could be used to make a new animal.

  • To explore the potential for cloning extinct animals.

  • To investigate the possibility of creating animals with human-like intelligence.

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